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Alcohol may increase drowsiness or dizziness while taking Paxil. Studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. With breakfast. Avoid drinking alcohol, which can increase some of the side effects of Paroxetine. Paxil is safe and effective for long-term use and is well tolerated. Paxil works by helping to restore the balance of certain natural chemicals in the brain.