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Prednisolone is used for treating several types of arthritis systemic lupus, allergic reactions, asthma and severe psoriasis. Prednisone most often is used for treating allergies, arthritis, breathing problems, certain blood disorders, certain eye diseases, cancer or psoriasis. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. A fungal infection anywhere in your body. Prednisone may interact with estrogens and phenytoin.